11-Hydroxy Yohimbine- If you are considering Meltdown for weight loss you can opt for yohimbine HCl. It should be taken before you have your meal. You can take it twice a day for losing weight. Half life of yohimbine is as less as one to two hours. At the same time, 11-Hydroxy Yohimbine, a metabolite also shows similar activities. The half life of 11-Hydroxy Yohimbine is approximately six to eight hours. You can take it after long periods as well. This acts like an extremely effective fat loss agent. Regular intake tends to result in 32 to 56% increase in the hormone that helps burn fat. This hormone can increase up to 81% if 11-Hydroxy Yohimbine is taken along with yohimbine contained in the meltdown blocking both alpha2 and alpha1 receptors.

Alpha-Yohimbine works with potent MAOI-inhibiting properties. In this context, it basically works like an amphetamine-potentiator, as it stops the neuro-breakdown of dopamine, noradrenaline and serotonin. Having similar alpha-2 antagonistic properties to yohimbine HCI, it is also less vasoconstrictive in areas, making it less likely for inducing increase in BP. It is an analogue of yohimbine, however there is a difference in its potency at the subreceptors of alpha2, most notably at alpha2c adrenergic and alpha2b subreceptors. This is 4 times more potent alpha2c and 3 times more potent at alpha2b. Yohimbine is an alkaloid which is found in a tree’s inner bark which grows in Southern Africa. It has been in use for centuries as an aphrodisiac. Today, it is primarily used in veterinary medicines and also for the treatment of erectile dysfunction. It is also used in treating obesity.